• Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study 

      Sedlmeier, Anja M.; Viallon, Vivian; Ferrari, Pietro; Peruchet-Noray, Laia; Fontvieille, Emma; Amadou, Amina; Seyed Khoei, Nazlisadat; Weber, Andrea; Baurecht, Hansjörg; Heath, Alicia K.; Tsilidis, Kostas; Kaaks, Rudolf; Katzke, Verena; Inan-Eroglu, Elif; Schulze, Matthias B.; Overvad, Kim; Bonet, Catalina; Ubago-Guisado, Esther; Chirlaque, María-Dolores; Ardanaz, Eva; Perez-Cornago, Aurora; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; Pasanisi, Fabrizio; Borch, Kristin Benjaminsen; Rylander, Charlotta; Weiderpass, Elisabete; Gunter, Marc J.; Fervers, Béatrice; Leitzmann, Michael F.; Freisling, Heinz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-02)
      Background - Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers.<p> <p>Methods - We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist ...
    • Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study 

      Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom G.; Ferrari, Pietro; Gunter, Marc J.; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos K.; Riboli, Elio; Muller, David; Purdue, Mark P.; Chanock, Stephen J.; Hung, Rayjean J.; Amos, Christopher I.; O'Mara, Tracy A.; Amiano, Pilar; Pasanisi, Fabrizio; Rodriguez-Barranco, Miguel; Krogh, Vittorio; Tjønneland, Anne; Halkjær, Jytte; Perez-Cornago, Aurora; Chirlaque, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin Benjaminsen; Aune, Dagfinn; Heath, Alicia K.; Ward, Heather A.; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Davey Smith, George; Brennan, Paul; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-19)
      It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was ...
    • Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts 

      Rothwell, Joseph A.; Bešević, Jelena; Dimou, Niki; Breeur, Marie; Murphy, Neil; Jenab, Mazda; Wedekind, Roland; Viallon, Vivian; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Scalbert, Augustin; Huybrechts, Inge; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Keun, Hector; Chadeau-Hyam, Marc; Boutron-Ruault, Marie-Christine; Overvad, Kim; Dahm, Christina C.; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Skeie, Guri; Zamora-Ros, Raul; Tsilidis, Kostas K.; Eichelmann, Fabian; Schulze, Matthias B.; van Guelpen, Bethany; Vidman, Linda; Sánchez, Maria-José; Amiano, Pilar; Ardanaz, Eva; Smith-Byrne, Karl; Travis, Ruth; Katzke, Verena; Kaaks, Rudolf; Derksen, Jeroen W. G.; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno-de-Mesquita, Bas; Vineis, Paolo; Palli, Domenico; Pasanisi, Fabrizio; Eriksen, Anne Kirstine; Tjønneland, Anne; Severi, Gianluca; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-28)
      Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulat‑ ing levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank ...
    • Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study 

      Heath, Alicia K.; Muller, David C.; van den Brandt, Piet A.; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Weiderpass, Elisabete; Boeing, Heiner; Ferrari, Pietro; Merritt, Melissa A.; Rostgaard-Hansen, Agnetha L.; Tjønneland, Anne; Overvad, Kim; Katzke, Verena; Srour, Bernard; Masala, Giovanna; Sacerdote, Carlotta; Ricceri, Fulvio; Pasanisi, Fabrizio; Bueno-de-Mesquita, Bas; Downward, George S.; Skeie, Guri; Sandanger, Torkjel M; Crous-Bou, Marta; Rodríguez-Barranco, Miguel; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Drake, Isabel; Johansson, Mikael; Johansson, Ingegerd; Key, Tim; Papadimitriou, Nikos; Riboli, Elio; Tzoulaki, Ioanna; Tsilidis, Konstantinos K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of ...
    • Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study 

      Córdova, Reynalda; Mayén, Ana-Lucia; Knaze, Viktoria; Aglago, Elom Kouassivi; Schalkwijk, Casper; Wagner, Karl-Heinz; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Katzke, Verena Andrea; Cornet, Charlotte Le; Schulze, Matthias Bernd; Birukov, Anna; Palli, Domenico; Grioni, Sara; Pasanisi, Fabrizio; Catalano, Alberto; Sandanger, Torkjel M; Gram, Inger Torhild; Skeie, Guri; Crous-Bou, Marta; Molina-Montes, Esther; Amiano, Pilar; Colorado-Yohar, Sandra Milena; Ardanaz, Eva; Drake, Isabel; Manjer, Jonas; Johansson, Ingegerd; Esberg, Anders; Perez-Cornago, Aurora; Weiderpass, Elisabete; Jenab, Mazda; Freisling, Heinz (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-04)
    • Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study 

      Aglago, Elom K.; Cross, Amanda J.; Riboli, Elio; Fedirko, Veronika; Hughes, David J.; Fournier, Agnes; Jakszyn, Paula; Freisling, Heinz; Gunter, Marc J.; Dahm, Christina C.; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Srour, Bernard; Schulze, Matthias B.; Wittenbecher, Clemens; Palli, Domenico; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Derksen, Jeroen W. G.; Skeie, Guri; Jensen, Torill; Lukic, Marko; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Barricarte, Aurelio; Ericson, Ulrika; van Guelpen, Bethany; Papier, Keren; Knuppel, Anika; Casagrande, Corinne; Huybrechts, Inge; Heath, Alicia K.; Tsilidis, Konstantinos K.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-09)
      Background - Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.<p> <p>Methods - We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the ...
    • Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Kliemann, Nathalie; Ammar, Romain Ould; Biessy, Carine; Gicquiau, Audrey; Katzke, Verena; Kaaks, Rudolf; Tjønneland, Anne; Olsen, Anja; Sánchez, Maria-Jose; Crous-Bou, Marta; Pasanisi, Fabrizio; Tin, Sandar Tin; Perez-Cornago, Aurora; Aune, Dagfinn; Christakoudi, Sofia; Heath, Alicia K.; Colorado-Yohar, Sandra M.; Grioni, Sara; Skeie, Guri; Sartor, Hanna; Idahl, Annika; Rylander, Charlotta; May, Anne M.; Weiderpass, Elisabete; Freisling, Heinz; Playdon, Mary C.; Rinaldi, Sabina; Murphy, Neil; Huybrechts, Inge; Dossus, Laure; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)
      Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known.<p> <p>Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case–control study (817 cases/ 817 controls) within the European Prospective Investigation ...
    • Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study 

      Hughes, David J.; Schomburg, Lutz; Jenab, Mazda; Biessy, Carine; Méplan, Catherine; Moskal, Aurelie; Sun, Qian; Demircan, Kamil; Fedirko, Veronika; Weiderpass Vainio, Elisabete; Mukhtar, Maryam; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Schulze, Matthias; Nøst, Therese Haugdahl; Skeie, Guri; Olsen, Karina Standahl; Ricceri, Fulvio; Grioni, Sara; Palli, Domenico; Masala, Giovanna; Tumino, Rosario; Pasanisi, Fabrizio; Amiano, Pilar; Colorado Yohar, Sandra M.; Agudo, Antonio; Sánchez, Maria-Jose; Ardanaz, Eva; Sund, Malin; Andersson, Anne; Perez-Cornago, Aurora; Travis, Ruth; Heath, Alicia K.; Dossus, Laure (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-01)
      Selenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3), in ...
    • Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition 

      Heath, Alicia K; Clasen, Johanna L; Jayanth, Nick P; Jenab, Mazda; Tjønneland, Anne; Petersen, Kristina E N; Overvad, Kim; Srour, Bernard; Katzke, Verena; Bergmann, Manuela M; Schulze, Matthias B; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Catalano, A; Pasanisi, Fabrizio; Brustad, Magritt; Olsen, Karina Standahl; Skeie, Guri; Lujan-Barroso, Leila; RodrÍguez-Barranco, Miguel; Amiano, Pilar; Santiuste, Carmen; Gurrea, Aurelio Barricarte; Axelson, Håkon; Ramne, Stina; Ljungberg, Börje; Watts, Eleanor L.; Huybrechts, Inge; Weiderpass, Elisabete; Riboli, Elio; Muller, David C (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)
      Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and ...